Losartan potassium

Catalog #: 3798
15 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
3798/50

Losartan potassium | CAS No. 124750-99-8 | Angiotensin AT1 Receptor Antagonists

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Description: Selective, non-peptide AT1 antagonist

Alternative Names: DuP-753

Chemical Name: 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt

Purity: ≥99%

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Product Details

Citations (15)

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Biological Activity

Losartan potassium is a selective non-peptide angiotensin AT₁ receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA₂ = 8.27). Orally active antihypertensive agent. Attenuates lung damage in a mouse model of SARS-CoV infection.

Technical Data

M.Wt:

461

Formula:

C₂₂H₂₂ClKN₆O

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥99%

Storage:

Desiccate at RT

CAS No:

124750-99-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus.
Tsai CY, Chan JY, Hsu KS
PLoS ONE, 2012;7(3):e33527.
Renal hemodynamic and morphological changes after 7 and 28 days of leptin treatment: the participation of angiotensin II via the AT1 receptor.
Thieme K, Oliveira-Souza M
PLoS ONE, 2015;10(3):e0122265.
Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).
Wong et al.
J.Pharmacol.Exp.Ther., 1990;255:584
Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP an orally active antihypertensive agent.
Wong et al.
J.Pharmacol.Exp.Ther., 1990;252:719
DuP 753 is a specific antagonist for the angiotensin receptor.
Rhaleb et al.
Hypertension, 1991;17:480
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.
Kuba et al.
Nat.Med., 2005;11:875

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Citations for Losartan potassium

The citations listed below are publications that use Tocris products. Selected citations for Losartan potassium include:

15 Citations: Showing 1 - 10

Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signaling.
Authors: Swen Et al.
Front Cell Neurosci 2023;17:1111263
Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids.
Authors: Justin Et al.
iScience 2022;25:103818
Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats.
Authors: Moreno-Santos Et al.
Behav.Brain Res. 2021;397
Substrate Stiffness and Stretch Regulate Profibrotic Mechanosignaling in Pulmonary Arterial Adventitial Fibroblasts.
Authors: Ariel Et al.
Cells 2021;10
The Impact of Ang-(1-9) and Ang-(3-7) on the Biological Properties of Prostate Cancer Cells by Modulation of Inflammatory and Steroidogenesis Pathway Genes.
Authors: Tomasz Et al.
Int J Mol Sci 2020;21
The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid.
Authors: Diego Et al.
Sci Signal 2020;13
Extracorporeal shock waves protect cardiomyocytes from DOX-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis.
Authors: Lee Et al.
Sci Rep 2019;9:12149
Angiotensin 1-7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer.
Authors: Dominska Et al.
Sci.Rep. 2018;8:15772
Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN.
Authors: Eero Et al.
Neuropharmacology 2018;135:163-171
Renal hemodynamic and morphological changes after 7 and 28 days of leptin treatment: the participation of angiotensin II via the AT1 receptor.
Authors: Thieme and Oliveira-Souza
PLoS One 2015;10:e0122265

Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling.
Authors: Santhekadur Et al.
FEBS Open Bio 2014;4:353

PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle.
Authors: Bhattachariya Et al.
Physiol Rep 2014;2

Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice.
Authors: Fang Et al.
Am J Physiol Heart Circ Physiol 2013;304:H816

Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus.
Authors: Tsai Et al.
EMBO Mol Med 2012;7:e33527

Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect.
Authors: Leite-Moreira Et al.
Br J Pharmacol 2006;147:690

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