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Leukotriene B4

Catalog #: 2307
1 Citation Datasheet / COA / SDS
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2307/50U
Leukotriene B4 | CAS No. 71160-24-2 | Leukotriene and Related Receptor Agonists
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Description: BLT1/BLT2 receptor agonist and potent chemotactic factor
Alternative Names: LTB4,5,12-DiHETE

Chemical Name: (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid

Purity: ≥95%

Product Details
Citations (1)
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Biological Activity

Leukotriene B4 is a potent lipid inflammatory mediator derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Binds to BLT1 and BLT2 receptors and acts as a potent chemotactic agent and activator of leukocytes. Also displays antiviral activity towards DNA viruses and retroviruses.

Technical Data

M.Wt:
336.47
Formula:
C20H32O4
Solubility:
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 50?g/ml)
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
71160-24-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Leukotriene B4: an inflammatory mediator in vivo.
    Bray et al.
    Prostaglandins, 1981;22:213
  2. Leukotriene B4 in inflammation.
    Ford-Hutchinson
    Crit.Rev.Immunol., 1990;10:1
  3. Leukotriene B4: metabolism and signal transduction.
    Yokomitso et al.
    Arch.Biochem.Biophys., 2001;385:231

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Citation for Leukotriene B4

The citations listed below are publications that use Tocris products. Selected citations for Leukotriene B4 include:

1 Citation: Showing 1 - 1

  1. Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B4-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1.
    Authors: Fernandes Et al.
    FASEB J  2013;27:1664

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