Lalistat 1
Chemical Name: 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate
Purity: ≥98%
Biological Activity
Lalistat 1 is a potent and selective lysosomal acid lipase (LAL) inhibitor (IC50 = 68 nM). Exhibits no significant activity against pancreatic lipase or lipoprotein lipase at 10 μM concentration. Blocks LAL-mediated lipid hydrolysis of acetylated LDL and reduces efflux of cholesterol from lipid-loaded cells resulting in increased cellular cholesterol ester levels.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors.
Rosenbaum et al.
Biochim.Biophys.Acta., 2009;1791:1155 -
Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase.
Ouimet et al.
Cell Metab., 2011;13:655 -
Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics.
Rosenbaum et al.
J.Med.Chem., 2010;53:5281
Product Datasheets
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Citations for Lalistat 1
The citations listed below are publications that use Tocris products. Selected citations for Lalistat 1 include:
3 Citations: Showing 1 - 3
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Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis.
Authors: Mariam Et al.
Autophagy 2021;17:690-705
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Evidence for a Novel Regulatory Interaction Involving Cyclin D1, Lipid Droplets, Lipolysis, and Cell Cycle Progression in Hepatocytes.
Authors: Wu Et al.
Hepatol Commun 2019;3:406
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Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes.
Authors: Shaun G Et al.
J Cell Biol 2019;218:3320-3335
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Used to inhibit IAP proteins to activate apoptosis
