L-817,818
Chemical Name: N2-[[2-(2-Naphthalenyl)-1H-benz[g]indol-3-yl]acetyl-D-lysine (2S)-2-aminopropyl ester
Purity: ≥99%
Biological Activity
L-817,818 is a potent and selective somatostatin sst5 receptor agonist. Ki values are 0.4, 3.3, 52, 64 and 82 nM for cloned human sst5, sst1, sst2, sst3 and sst4 receptors respectively. Inhibits growth hormone release from rat pituitary cells (EC50 = 3.1 nM) and insulin release from mouse pancreatic islets (EC50 = 0.3 nM) in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification and characterization of subtype selective somatostatin receptor agonists.
Rohrer and Schaeffer
J.Physiol.Paris, 2000;94:211 -
Somatostatin inhibits Ins and glucagon secretion via two receptor subtypes: An in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice.
Strowski et al.
Endocrinology, 2000;141:111 -
Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
Rohrer et al.
Science, 1998;282:737
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