L-748,337
Chemical Name: N-[[3-[(2S)-2-Hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl]-acetamide
Purity: ≥98%
Biological Activity
L-748,337 is a competitive β3-adrenoceptor antagonist that displays selectivity over β1 and β2 receptors (Ki values are 4.0, 204 and 390 nM for β3-, β2- and β1-adrenoceptors respectively). Inhibits cAMP accumulation in response to Isoproterenol (IC50 = 6 nM). Reduces iNOS expression, attenuates nitric oxide-induced cell proliferation and induces apoptosis in a melanoma cell line.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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β3-adrenergic receptor activity modulates melanoma cell proliferation and survival through nitric oxide signaling.
Dal Monte et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2014;387:533 -
Potent and selective human β3-adrenergic receptor antagonist.
Candelore et al.
J.Pharmacol.Exp.Ther., 1999;290:649 -
The function of α- and β-adrenoceptors of the saphenous artery in caveolin-1 knockout and wild-type mice.
Neidhold et al.
Br.J.Pharmacol., 2007;150:261
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