Home / CCK2 Receptor Antagonists / L-365,260

L-365,260

Catalog #: 2767
1 Citation Datasheet / COA / SDS
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L-365,260 | CAS No. 118101-09-0 | CCK2 Receptor Antagonists
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Description: Selective CCK2 antagonist

Chemical Name: N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

L-365,260 is a selective cholecystokinin receptor 2 (CCK2) antagonist (IC50 values are 2 and 280 nM at CCK2 and CCK1 receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α- and β adrenergic, histamine, angiotensin and bradykinin receptors.

Technical Data

M.Wt:
398.46
Formula:
C24H22N4O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
118101-09-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Ex Vivo Human Pancreatic Slice Preparations Offer a Valuable Model for Studying Pancreatic Exocrine Biology
    T Liang, S Dolai, L Xie, E Winter, AI Orabi, N Karimian, LI Cosen-Bink, YC Huang, P Thorn, M Cattral, HY Gaisano
    J. Biol. Chem, 2017;0(0):.
  2. Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260.
    Kees et al.
    J.Med.Chem., 1989;32:13
  3. A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260.
    Lotti and Chang
    Eur.J.Pharmacol., 1989;162:273
  4. Cholecystokinin action on layer 6b neurons in somatosensory cortex.
    Chung et al.
    Brain Res., 2009;1282:10

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Citation for L-365,260

The citations listed below are publications that use Tocris products. Selected citations for L-365,260 include:

1 Citation: Showing 1 - 1

  1. Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol.
    Authors: Wu Et al.
    Toxicol Sci  2014;138:278

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