L-152,804
Chemical Name: 5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione
Purity: ≥99%
Biological Activity
L-152,804 is a potent, selective non-peptide neuropeptide Y Y5 receptor antagonist (Ki = 26 nM for hY5). Displays > 300-fold selectivity over hY1, hY2, and hY4 receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Fasting induces a form of autonomic synaptic plasticity that prevents hypoglycemia.
Wang M, Wang Q, Whim M
Proc Natl Acad Sci U S A, 0;113(21):E3029-38. -
L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist.
Kanatani et al.
Biochem.Biophys.Res.Commun., 2000;272:169 -
A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.
Mashiko et al.
Mol.Pharmacol., 2007;71:602 -
The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol self-administration in inbred alcohol-preferring (iP) rats.
Schroeder et al.
Alcohol, 2005;36:179
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Citations for L-152,804
The citations listed below are publications that use Tocris products. Selected citations for L-152,804 include:
9 Citations: Showing 1 - 9
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Platelet Lysate-Derived Neuropeptide y Influences Migration and Angiogenesis of Human Adipose Tissue-Derived Stromal Cells.
Authors: Businaro Et al.
Sci Rep 2018;8(1):14365
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Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.
Authors: Martins Et al.
ASN Neuro 2015;7
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Neuropeptide Y stimulates autophagy in hypothalamic neurons.
Authors: Aveleira Et al.
Cell Death Dis 2015;112:E1642
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Long-Term Over-Expression of Neuropeptide Y in Hypothalamic Paraventricular Nucleus Contributes to Adipose Tissue Ins Resistance Partly via the Y5 Receptor.
Authors: Long Et al.
J Pharmacol Exp Ther 2015;10:e0126714
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Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate.
Authors: Santos-Carvalho Et al.
Neuropsychopharmacology 2013;4:e636
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Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells.
Authors: Ferreira Et al.
J Biol Chem 2011;8:169
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Neuropeptide Y modulation of interleukin-1{β} (IL-1{β})-induced nitric oxide production in microglia.
Authors: Ferreira Et al.
Proc Natl Acad Sci U S A 2010;285:41921
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Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures.
Authors: Woldbye Et al.
Brain 2010;133:2778
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A novel long-acting selective neuropeptide Y2 receptor polyethylene glycol-conjugated peptide agonist reduces food intake and body weight and improves glucose metabolism in rodents.
Authors: Ortiz Et al.
J Neuroinflammation 2007;323:692
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