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KL 001

Catalog #: 4685 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4685/10
4685/50
KL 001 | CAS No. 309928-48-1 | Additional Transcription Factor Compounds
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Description: Cryptochrome protein stabilizer; lengthens circadian period

Chemical Name: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide

Purity: ≥98%

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Biological Activity

KL 001 is a cryptochrome protein (CRY) stabilizer; blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Represses glucagon-induced hepatic gluconeogenesis through the induction of Pck1 and G6pc expression.

Technical Data

M.Wt:
398.48
Formula:
C21H22N2O4S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
309928-48-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of small molecule activators of cryptochrome.
    Hirota et al.
    Science, 2012;337:1094

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