K 41498
Purity: ≥95%
Biological Activity
K 41498 is a potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats in vivo, blocks urocortin-induced hypotension following systemic administration.Technical Data
(Modifications: Phe-1 = D-Phe, X = Nle, Ile-30 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Design, synthesis and pharmacological characterization of new highly selective CRF2 antagonists: development of 123I-K31440 as a potential SPECT ligand.
Ruhmann et al.
Peptides, 2002;23:453 -
The highly selective CRF2 receptor antagonist K41498 binds to presynaptic CRF2 receptors in rat brain.
Lawrence et al.
Br.J.Pharmacol., 2002;136:896
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Citation for K 41498
The citations listed below are publications that use Tocris products. Selected citations for K 41498 include:
1 Citation: Showing 1 - 1
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Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.
Authors: Nakamura and Sapru
Am J Physiol Heart Circ Physiol 2009;296:H2022
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