JNJ 5207852 dihydrochloride
Chemical Name: 1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochloride
Purity: ≥99%
Biological Activity
JNJ 5207852 dihydrochloride is a high affinity histamine H3 receptor neutral antagonist (pKi values are 8.9 and 9.2 in rat and human respectively). Brain penetrant and orally active. Has 3- and 100-fold higher affinity than thioperamide (Cat. No. 0644) for rat and human H3 receptors respectively. Suppresses slow-wave sleep; exhibits wake-promoting effects in rodent arousal models.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist.
Barbier et al.
Br.J.Pharmacol., 2004;143:649 -
Correlation between ex vivo receptor occupancy and wake-promoting activity of selective H3 receptor antagonists.
Le et al.
J.Pharmacol.Exp.Ther., 2008;325:902 -
Effects of histamine H3 antagonists and donep. on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.
Jia et al.
Neuropharmacology, 2005;50:404
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