JHW 007 hydrochloride
Chemical Name: (3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane hydrochloride
Purity: ≥99%
Biological Activity
JHW 007 hydrochloride is a dopamine uptake inhibitor; displays high affinity for the dopamine transporter (DAT) (Ki = 25 nM compared to 1330 and 1730 for NET and SERT respectively). Suppresses the effects of cocaine administration in a dose-dependent manner and decreases cocaine and methamphetamine self-administration in rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The high affinity DA uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization.
Velaquez-Sanchez et al.
Eur.Neuropsychopharmacol., 2010;20:501 -
DA transporter-dependent and -independent striatal binding of the benztr. analog JHW 007, a cocaine antagonist with low abuse liability.
Kopajtic et al.
J.Pharmacol.Exp.Ther., 2010;335:703 -
Preclinical efficacy of N-substituted benztr. analogs as antagonists of metha. self-administration in rats.
Hiranita et al.
J.Pharmacol.Exp.Ther., 2014;348:174
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Citation for JHW 007 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for JHW 007 hydrochloride include:
1 Citation: Showing 1 - 1
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Binding site residues control inhibitor selectivity in the human NE transporter but not in the human DA transporter.
Authors: Andersen Et al.
Stem Cell Reports 2015;5:15650
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