J 2156

Biological Activity

J 2156 is a high affinity human somatostatin receptor 4 (sst₄) agonist (K_i = 1.2 nM). Displays >400-fold selectivity for human sst₄ over other human sst receptor subtypes. Exhibits 2 to 3-fold more potent agonism in vitro than endogenous ligands somatostatin-14 (Cat. No. 1157) and somatostatin-28 (Cat. No. 1165). Reduces inflammatory airway hyperresponsiveness in acute and chronic airway inflammation models in mice. Exhibits anxiolytic effects in elevated plus maze test in mice.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse.
   Elekes et al.
   Eur.J.Pharmacol., 2008;578:313
2. Superagonism at the human somatostatin receptor subtype 4.
   Engström et al.
   J.Pharmacol.Exp.Ther., 2005;312:332
3. Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models.
   Scheich et al.
   Neuropharmacology., 2016;101:204

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