ITE
Chemical Name: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester
Purity: ≥98%
Biological Activity
ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR.
Wu Y, Chen X, Zhou Q, He Q, Kang J, Zheng J, Wang K, Duan T
PLoS ONE, 2014;9(1):e86549. -
Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis.
Proc Natl Acad Sci U S A, 2012;109(28):11270-5. -
An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells.
Wang et al.
Cancer Lett., 2013;340:63 -
The aryl hydrocarbon receptor ligand ITE inhibits TGF�1-induced human myofibroblast differentiation.
Lehmann et al.
Am.J.Pathol., 2011;178:1556 -
Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells.
Cheng et al.
Nat.Commun., 2015;6:7209 -
A ligand for the aryl hydrocarbon receptor isolated from lung.
Song et al.
Proc.Natl.Acad.Sci.U.S.A., 2002;99:14694
Product Datasheets
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Citations for ITE
The citations listed below are publications that use Tocris products. Selected citations for ITE include:
9 Citations: Showing 1 - 9
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Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome.
Authors: Boule
Sci Rep 2018;8(1):1826
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Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of "luminal" muscle-invasive bladder cancers.
Authors: Baker Et al.
Mol Carcinog 2018;57:606
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Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses.
Authors: Iyer Et al.
Cell 2018;173:1123
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HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus.
Authors: Fusco Et al.
Front Microbiol 2017;8:240
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ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR.
Authors: Wu Et al.
PLoS One 2014;9:e86549
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Decreased expression of the aryl hydrocarbon receptor in ocular Behcet's disease.
Authors: Wang Et al.
Mediators Inflamm 2014;2014:195094
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ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity.
Authors: Nugent Et al.
PLoS One 2013;54:7463
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An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells.
Authors: Wang Et al.
Cancer Lett 2013;340:63
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Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis.
Authors: Yeste Et al.
Proc Natl Acad Sci U S A 2012;109:11270
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