IRAK1/4 Inhibitor I
Chemical Name: N-[1-[2-(4-Morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitrobenzamide
Purity: ≥98%
Biological Activity
IRAK1/4 Inhibitor I is an IRAK4 and IRAK1 inhibitor (IC50 values are 0.2 and 0.3 μM, respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.
Powers et al.
Bioorg.Med.Chem.Lett., 2006;16:2842 -
Bcl10 Regulates Lipopolysaccharide-Induced Pro-Fibrotic Signaling in Bronchial Fibroblasts from Severe Asthma Patients
RK Ramakrishn, K Bajbouj, M Guimei, SS Rawat, Z Kalaji, MY Hachim, B Mahboub, SM Ibrahim, R Hamoudi, R Halwani, Q Hamid
Biomedicines, 2022;10(7):.
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Citation for IRAK1/4 Inhibitor I
The citations listed below are publications that use Tocris products. Selected citations for IRAK1/4 Inhibitor I include:
1 Citation: Showing 1 - 1
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SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut.
Authors: Shahid Et al.
Cell Mol Gastroenterol Hepatol 2021;13:425-440
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