(-)-Indolactam V
Chemical Name: (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
Purity: ≥99%
Biological Activity
Protein kinase C activator. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
Chen et al.
Nat.Chem.Biol., 2009;5:258 -
Activation of protein kinase C subtypes α, γ, δ, ε, ζ and η by tumor-promoting and nontumor-promoting agents.
Geiges et al.
Biochem.Pharmacol., 1997;53:865 -
Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes.
Masuda et al.
Biosci.Biotechnol.Biochem., 2002;66:1615
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