Imetit dihydrobromide
Chemical Name: 5-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide
Purity: ≥98%
Biological Activity
Imetit dihydrobromide is an an extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats.
Farzin and Attarzadeh
Eur.J.Pharmacol., 2000;404:169 -
S-[2-(4-Imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist.
Garbarg et al.
J.Pharmacol.Exp.Ther., 1992;263:304 -
Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation.
Ling et al.
Br.J.Pharmacol., 2004;142:161
Product Datasheets
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Citations for Imetit dihydrobromide
The citations listed below are publications that use Tocris products. Selected citations for Imetit dihydrobromide include:
3 Citations: Showing 1 - 3
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Histamine 3 receptor activation reduces the expression of neuronal angiotensin II type 1 receptors in the heart.
Authors: Hashikawa-Hobara Et al.
Evid Based Complement Alternat Med 2012;340:185
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Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus.
Authors: Yoshimoto Et al.
Proc Natl Acad Sci U S A 2006;103:13866
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Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP.
Authors: Flamand Et al.
Br J Pharmacol 2004;141:552
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