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Human VE-Statin Antibody

Catalog #: AF3638
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF3638
AF3638-SP
Product Details
Citations (5)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human VE-Statin Antibody Summary

Species Reactivity
Human
Specificity
Detects human VE-Statin in direct ELISAs and Western blots. In Western blots, approximately 10% cross-reactivity with recombinant mouse VE-Statin is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human VE-Statin
Glu21-Ser273
Accession # BAD01469
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human VE-Statin

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: VE-Statin

VE-Statin, also known as epidermal growth factor-like domain 7 (EGFL7), is a secreted endothelial-specific protein that is a marker for progenitor, embryonic and adult endothelial cells. Mature soluble VE-Statin is a 41 kDa protein containing an N-terminal cysteine-rich EMI domain, followed by two EGF-like domains and a coiled-coil region. VE-Statin inhibits PDGF-BB-induced smooth muscle cell migration. The amino acid sequence of human VE-Statin is 80% identical to that of mouse VE-Statin.

Long Name
Vascular Endothelial Statin/EGF-like Domain, Multiple 7
Entrez Gene IDs
51162 (Human)
Alternate Names
EGFL7; EGF-like protein 7; EGF-like-domain, multiple 7; epidermal growth factor-like protein 7; MEGF7; MGC111117; Multiple EGF-like domains protein 7; Multiple epidermal growth factor-like domains protein 7; NEU1 protein; NOTCH4-like protein; RP11-251M1.2; Vascular endothelial statin; VEStatin; VE-Statin; ZNEU1

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Citations for Human VE-Statin Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Increased circulating levels of Epidermal Growth Factor-like Domain 7 in pregnant women affected by preeclampsia
    Authors: Micol Massimiani, Lauretta A. Lacko, CLARE S. BURKE Burke Swanson, Silvia Salvi, Lissenya B. Argueta, Sascia Moresi et al.
    Translational Research
  2. Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer
    Authors: GÉRALDINE PHILIPPIN-LAURIDANT, MARIE-CHRISTINE BARANZELLI, CHANTAL SAMSON, CHARLES FOURNIER, SÉBASTIEN PINTE, VIRGINIE MATTOT et al.
    International Journal of Oncology
  3. Epidermal Growth Factor Like-domain 7 and miR-126 are abnormally expressed in diffuse Systemic Sclerosis fibroblasts
    Authors: V Liakouli, P Cipriani, P Di Benedet, N Panzera, P Ruscitti, I Pantano, O Berardicur, F Carubbi, F Esteves, G Mavria, F Del Galdo, R Giacomelli
    Sci Rep, 2019-03-14;9(1):4589.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. Endothelial Cell Activation is Regulated by Epidermal Growth Factor-Like Domain 7 (Egfl7) during Inflammation
    J Biol Chem, 2016-09-20;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  5. VE-statin/egfl7 regulates vascular elastogenesis by interacting with lysyl oxidases.
    Authors: Lelievre E, Hinek A, Lupu F, Buquet C, Soncin F, Mattot V
    EMBO J., 2008-05-22;27(12):1658-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC

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