Human RIPK3/RIP3 (NP_006862) VersaClone cDNA

Catalog # Availability Size / Price Qty
RDC2118
R&D Systems VersaClone cDNA Plasmids
1 Image
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Human RIPK3/RIP3 (NP_006862) VersaClone cDNA Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

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Background: RIPK3/RIP3

RIPK3 (), also known as RIP3, is a 518 amino acid (aa), 60 kDa phosphoprotein that contains an N-terminal protein kinase domain and a C-terminal interaction motif with which it binds RIPK1. It converts cell response to TNF-alpha from apoptosis (RIPK1 via Fas) to programmed necrosis (RIPK1/RIPK3) by inducing reactive oxygen species production. Alternately spliced human beta (252 aa) and gamma (231 aa) isoforms diverge after aa 219 and 221, respectively, and are found to antagonize RIP3.

Long Name
Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 3
Entrez Gene IDs
11035 (Human); 56532 (Mouse); 246240 (Rat)
Alternate Names
EC 2.7.11.1; Receptor Interacting Serine/Threonine Kinase 3; Receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; receptor-interacting serine-threonine kinase 3; RIP3; RIP-3; RIPK3; RIP-like protein kinase 3

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