Human Plasminogen/Plasmin Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Plasminogen
Plasminogen (PLG) is the precursor of Plasmin, an active serine protease that dissolves the fibrin of blood clots and acts in many other processes such as embryonic development, tissue remodeling, inflammation and tumor invasion (1, 2). Synthesized in the kidney, Plasminogen is found in plasma and many extracellular fluids. Activated by u- or t-Plasminogen Activator, the single‑chain Plasminogen (aa 20-810) is converted to Plasmin, which consists of disulfide bond‑linked heavy chain A (aa 20-580) and light chain B (aa 581-810). Heavy chain A contains 5 kringle domains and light chain B corresponds to the serine protease domain. A fragment consisting of the first 4 kringle domains has been named Angiostatin, an angiogenesis inhibitor (3, 4).
- Petersen, T.E. et al. (1990) J. Biol. Chem. 265:6104.
- Forsgren, M. et al. (1987) FEBS Lett. 213:254.
- O’Reilly, M.S. et al. (1994) Cell 79:315.
- Sim, B.K. et al. (1997) Cancer Res. 57:1329.
Product Datasheets
Citations for Human Plasminogen/Plasmin Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 5
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Trial of Amiloride in Type 2 Diabetes With Proteinuria
Authors: Mark L. Unruh, V. Shane Pankratz, John E. Demko, Evan C. Ray, Rebecca P. Hughey, Thomas R. Kleyman
Kidney International Reports
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Exposure of HL-60 human leukaemic cells to 4-hydroxynonenal promotes the formation of adduct(s) with alpha-enolase devoid of plasminogen binding activity.
Authors: Gentile F, Pizzimenti S, Arcaro A, Pettazzoni P, Minelli R, D'Angelo D, Mamone G, Ferranti P, Toaldo C, Cetrangolo G, Formisano S, Dianzani MU, Uchida K, Dianzani C, Barrera G
Biochem. J., 2009-08-13;422(2):285-94.
Species: Human
Sample Types: Recombinant Protein
Applications: Western Blot -
Immunogenic and plasminogen-binding surface-associated alpha-enolase of Trichomonas vaginalis.
Authors: Mundodi V, Kucknoor AS, Alderete JF
Infect. Immun., 2007-12-10;76(2):523-31.
Species: Human
Sample Types: Recombinant Protein
Applications: Western Blot -
Fibrin derived from patients with chronic thromboembolic pulmonary hypertension is resistant to lysis.
Authors: Morris TA, Marsh JJ, Chiles PG, Auger WR, Fedullo PF, Woods VL
Am. J. Respir. Crit. Care Med., 2006-03-02;173(11):1270-5.
Species: Human
Sample Types: Plasma
Applications: Western Blot -
Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface
Authors: Milena M. Awad, Melanie L. Hutton, Adam J. Quek, William P. Klare, Steven J. Mileto, Kate Mackin et al.
Gastroenterology
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Antibody was printed on custom arrays and incubated with fluorescently labeled human EDTA plasma
