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Human Neuregulin-1/NRG1 Antibody

Catalog #: MAB377
85 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB377-SP
MAB377-100
MAB377-500
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Citations (85)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Neuregulin-1/NRG1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human Neuregulin‑1/NRG1 in direct ELISAs and Western blots. In direct ELISAs, no cross‑reactivity with the EGF‑like domains of recombinant human (rh) NRG1-beta 1 (aa 176‑246) or rhNRG1-alpha (aa 177‑241). Therefore, this antibody recognizes an epitope located within aa 2‑176 segment N‑terminal to the EGF‑like domain. This segment is present in all NRG1‑ alpha, beta and gamma isoforms and in NDF43 and glial growth factor (GGF). It is absent from the NRG1 gene products GGF2 and SMDF.
Source
Monoclonal Mouse IgG2B Clone # 147724
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human Neuregulin‑1/NRG1
Ser2-Lys246
Accession # AAA58639
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human Neuregulin‑1/NRG1 (Catalog # 5898-NR)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Neuregulin-1/NRG1

The Neuregulin family of structurally related glycoproteins comprises products from four distinct but related genes, Nrg-1, Nrg-2, Nrg-3, and Nrg-4. Through alternative splicing or the use of alternative promoters, Nrg-1 has been shown to encode more than 14 soluble or transmembrane proteins. The extracellular domain of the transmembrane NRG1 isoforms can be proteolytically cleaved to release soluble growth factors. All NRG1 isoforms contain an EGF-like domain ( alpha - or beta -splice variant that differ in their C-terminal region) that is required for their direct binding to the ErbB3 or ErbB4 receptor tyrosine kinases. The ErbB3 or ErbB4 subsequently recruits and heterodimerizes with ErbB2, resulting in tyrosine phosphorylation and NRG1 signaling. NRG1 isoforms can be classified into three major subtypes. Type I (Neu Differentiation Factor, NDF; Heregulin, HRG; Acetylcholine Receptor Inducing Activity, ARIA) and type II (Glial Growth Factor, GGF) NRG1s have an immunoglobulin (Ig)-like domain N-terminal to the EGF-like domain. Type I NRG1s differ from type II NRG1s by having a glycosylation-rich domain between the Ig-like and the EGF-like domains. Type III NRG1s (Sensory and Motor neuron-Derived Factor) lacks the Ig-like domain but has a cysteine rich domain (CRD) instead. NRG1 isoforms show distinct spatial and temporal expression patterns. These proteins play important roles during development of both the nervous system and the heart. They have been shown to regulate the selective expression of neurotransmitter receptors in neurons and at the neuromuscular junction, and promote the differentiation and development of Schwann cells from neural crest stem cells. NRG1s have also been shown to be involved in the establishment of the oligodendroglial lineage.

References
  1. Buonanno, A., and G.D Fischbach (2001) Curr. Opin. Neurobiol. 11:287.
  2. Adlkofer, K. and C. Lai (2000) Glia 29:104.
  3. Garratt, A.N. et al., (2000) BioEssays 22:987.
Entrez Gene IDs
3084 (Human); 211323 (Mouse); 112400 (Rat)
Alternate Names
ARIA; GGF2; GGFglial growth factor; Heregulin-1; HGL; HGLneu differentiation factor; HRG; HRG1; HRG1-alpha; HRG1-beta 1; HRGAneuregulin 1 type IV beta 1a; MST131; MSTP131; NDFheregulin, alpha (45kD, ERBB2 p185-activator); neuregulin 1 type IV beta 3; neuregulin 1; Neuregulin1; Neuregulin-1; NRG1; pro-neuregulin-1, membrane-bound isoform; pro-NRG1; sensory and motor neuron derived factor; SMDF

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Citations for Human Neuregulin-1/NRG1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

85 Citations: Showing 1 - 10
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  1. Chronic L-Dopa Decreases Serotonin Neurons in a Sub-region of the Dorsal Raphe Nucleus.
    Authors: Stansley BJ, Yamamoto BK.
    J Pharmacol. Exp. Ther.
  2. Alpha-Synuclein Pathology Coincides With Increased Number of Early Stage Neural Progenitors in the Adult Hippocampus
    Authors: Bender H, Fietz Sa, Richter F, Stanojlovic M
    Frontiers in cell and developmental biology
  3. cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury
    Authors: Y Li, JW Jones, H M C Choi, C Sarkar, MA Kane, EY Koh, MM Lipinski, J Wu
    Cell Death Dis, 2019-07-11;10(7):531.
  4. Upregulation of Mlxipl induced by cJun in the spinal dorsal horn after peripheral nerve injury counteracts mechanical allodynia by inhibiting neuroinflammation
    Authors: Zhan H, Wang Y, Yu S et al.
    Aging (Albany NY)
  5. Rap1 in the VMH regulates glucose homeostasis
    Authors: K Kaneko, HY Lin, Y Fu, PK Saha, AB De la Puen, Y Xu, K Ohinata, P Chen, A Morozov, M Fukuda
    JCI Insight, 2021-06-08;0(0):.
  6. A new genetic strategy for targeting microglia in development and disease
    Authors: McKinsey GL, Lizama CO, Keown-Lang AE et al.
    Elife
  7. HIV-1 Tat and morphine decrease murine inter-male social interactions and associated oxytocin levels in the prefrontal cortex, amygdala, and hypothalamic paraventricular nucleus
    Authors: Nass SR, Lark ARS, Hahn YK et al.
    Hormones and behavior
  8. mTOR inhibition as a novel gene therapeutic strategy for diabetic retinopathy
    Authors: SHS Lee, JY Lee, JS Choi, HJ Kim, J Kim, S Cha, KJ Lee, HN Woo, K Park, H Lee
    PLoS ONE, 2022-06-16;17(6):e0269951.
  9. Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury.
    Authors: Piao CS, Loane DJ, Stoica B et al.
    Neurobiol Dis.
  10. The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development
    Authors: T Gu, D Hao, J Woo, TW Huang, L Guo, X Lin, AG Guzman, A Tovy, C Rosas, M Jeong, Y Zhou, B Deneen, Y Huang, W Li, MA Goodell
    Nature Genetics, 2022-05-09;54(5):625-636.
  11. Antenatal low-intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone-induced intrauterine growth restriction
    Authors: Hung TH, Liu YC, Wu CH et al.
    Brain pathology (Zurich, Switzerland)
  12. Courtship song preferences in female zebra finches are shaped by developmental auditory experience.
    Authors: Chen Y, Clark O, Woolley SC.
    Proc. Biol. Sci.
  13. Hypoxia-Ischemia and Hypothermia Independently and Interactively Affect Neuronal Pathology in Neonatal Piglets with Short-Term Recovery.
    Authors: O'Brien, C E, Santos, P T Et al.
    Dev Neurosci
  14. Extracellular vesicles derived from mesenchymal stem cells alleviate neuroinflammation and mechanical allodynia in interstitial cystitis rats by inhibiting NLRP3 inflammasome activation
    Authors: Zhang C, Huang Y, Ouyang F et al.
    Journal of neuroinflammation
  15. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice
    Authors: JM Castellano, KI Mosher, RJ Abbey, AA McBride, ML James, D Berdnik, JC Shen, B Zou, XS Xie, M Tingle, IV Hinkson, MS Angst, T Wyss-Coray
    Nature, 2017-04-19;544(7651):488-492.
  16. Perineuronal Nets in Spinal Motoneurones: Chondroitin Sulphate Proteoglycan around Alpha Motoneurones
    Authors: SF Irvine, JCF Kwok
    Int J Mol Sci, 2018-04-12;19(4):.
  17. TRAIL Mediates Neuronal Death in AUD: A Link between Neuroinflammation and Neurodegeneration
    Authors: Qin L, Zou J, Barnett A et al.
    International Journal of Molecular Sciences
  18. The angiogenic factor angiopoietin-1 is a proneurogenic peptide on subventricular zone stem/progenitor cells.
    Authors: Rosa AI, Goncalves J, Cortes L, Bernardino L, Malva JO, Agasse F
    J. Neurosci., 2010-03-31;30(13):4573-84.
  19. Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid ? aggregates in vivo in a mouse model of Alzheimer's disease
    Authors: Calvo-Rodriguez, M;Kharitonova, EK;Snyder, AC;Hou, SS;Sanchez-Mico, MV;Das, S;Fan, Z;Shirani, H;Nilsson, KPR;Serrano-Pozo, A;Bacskai, BJ;
    Molecular neurodegeneration
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  20. PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus
    Authors: Hornung RS, Kinchington PR, Umorin M, Kramer PR
    Molecular pain
  21. Rab7a activation promotes degradation of select tight junction proteins at the blood-brain barrier after ischemic stroke
    Authors: Cottarelli A, Shahriar S, Arac A et al.
    bioRxiv
  22. Microglial REV-ERB alpha regulates inflammation and lipid droplet formation to drive tauopathy in male mice
    Authors: Jiyeon Lee, Julie M. Dimitry, Jong Hee Song, Minsoo Son, Patrick W. Sheehan, Melvin W. King et al.
    Nature Communications
  23. Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions
    Authors: Tai YH, Engels D, Locatelli G et al.
    Nature Metabolism
  24. Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABAA receptor transport in a murine model
    Authors: Liu J, Ke P, Guo H et al.
    Experimental & molecular medicine
  25. A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner
    Authors: Traunm�ller L, Schulz J, Ortiz R et al.
    Cell reports
  26. Contrasting patterns of somatic mutations in neurons and glia reveal differential predisposition to disease in the aging human brain
    Authors: Ganz J, Luquette LJ, Bizzotto S et al.
    bioRxiv : the preprint server for biology
  27. Essential role of the mitochondrial Na+/Ca2+ exchanger NCLX in mediating PDE2-dependent neuronal survival and learning
    Authors: Maya Rozenfeld, Ivana Savic Azoulay, Tsipi Ben Kasus Ben Kasus Nissim, Alexandra Stavsky, Moran Melamed, Grace Stutzmann et al.
    Cell Reports
  28. SYK coordinates neuroprotective microglial responses in neurodegenerative disease
    Authors: Hannah Ennerfelt, Elizabeth L. Frost, Daniel A. Shapiro, Coco Holliday, Kristine E. Zengeler, Gabrielle Voithofer et al.
    Cell
  29. Deciphering the dynamic niches and regeneration-associated transcriptional program of motoneurons following peripheral nerve injury
    Authors: Yu Zhang, Lian Xu, Xiaodi Li, Zhifeng Chen, Jing Chen, Tao Zhang et al.
    iScience
  30. Adding of neurotensin to non-small cell lung cancer cells increases tyrosine phosphorylation of HER3
    Authors: TW Moody, I Ramos-Alva, RT Jensen
    Peptides, 2022-08-03;156(0):170858.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  31. Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain
    Authors: Vicario N, Denaro S, Turnaturi R et al.
    International Journal of Molecular Sciences
  32. Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following traumatic brain injury in mice
    Authors: Qiu-Yuan Chen, Heng-Li Tian, Qiu-Yuan Gong, Lin Wang, Dian-Xu Jing, Shi-Wen Wang et al.
    Neural Regeneration Research
  33. Kidins220/ARMS modulates brain morphology and anxiety-like traits in adult mice
    Authors: Amanda Almacellas-Barbanoj, Martina Albini, Annyesha Satapathy, Fanny Jaudon, Caterina Michetti, Alicja Krawczun-Rygmaczewska et al.
    Cell Death Discovery
  34. Chemogenetic stimulation of the G(i) pathway in astrocytes suppresses neuroinflammation
    Authors: Kim JH, Rahman MH, Lee WH, Suk K.
    Pharmacology Research & Perspectives
  35. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model
    Authors: Wang W, Cao Q, Tan T et al.
    Aging Cell
  36. Highly efficient manipulation of nervous system gene expression with NEPTUNE
    Authors: Katrin Mangold, Jan Mašek, Jingyan He, Urban Lendahl, Elaine Fuchs, Emma R. Andersson
    Cell Reports Methods
  37. Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers
    Authors: Ruyi Mei, Linyu Huang, Mengyuan Wu, Chunxia Jiang, Aifen Yang, Huaping Tao et al.
    Frontiers in Cellular Neuroscience
  38. An N-terminal fusion allele to study melanin concentrating hormone receptor 1
    Authors: Jasso KR, Kamba TK, Zimmerman AD et al.
    genesis
  39. mTOR kinase inhibition disrupts neuregulin 1-ERBB3 autocrine signaling and sensitizes NF2-deficient meningioma cellular models to IGF1R inhibition
    Authors: RL Beauchamp, S Erdin, L Witt, JT Jordan, SR Plotkin, JF Gusella, V Ramesh
    The Journal of Biological Chemistry, 2020-12-09;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  40. The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect
    Authors: C. Chalfouh, C. Guillou, J. Hardouin, Q. Delarue, X. Li, C. Duclos et al.
    Neurotherapeutics
  41. Parenchymal pericytes are not the major contributor of extracellular matrix in the fibrotic scar after stroke in male mice
    Authors: Michaela Roth, Andreas Enström, Candice Aghabeick, Robert Carlsson, Guillem Genové, Gesine Paul
    Journal of Neuroscience Research
  42. Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B
    Authors: Anita Grover, Danielle Crippen-Harmon, Lacey Nave, Jon Vincelette, Jill C. M. Wait, Andrew C. Melton et al.
    Drug Delivery and Translational Research
  43. Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates
    Authors: Andrew S. Fox, Tade Souaiaia, Jonathan A. Oler, Rothem Kovner, Jae Mun (Hugo) Kim, Joseph Nguyen et al.
    Biological Psychiatry
  44. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model
    Authors: L Zhong, Y Xu, R Zhuo, T Wang, K Wang, R Huang, D Wang, Y Gao, Y Zhu, X Sheng, K Chen, N Wang, L Zhu, D Can, Y Marten, M Shinohara, CC Liu, D Du, H Sun, L Wen, H Xu, G Bu, XF Chen
    Nat Commun, 2019-03-25;10(1):1365.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  45. miR-296-5p suppresses EMT of hepatocellular carcinoma via attenuating NRG1/ERBB2/ERBB3 signaling
    Authors: DM Shi, LX Li, XY Bian, XJ Shi, LL Lu, HX Zhou, TJ Pan, J Zhou, J Fan, WZ Wu
    J. Exp. Clin. Cancer Res., 2018-11-29;37(1):294.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  46. The basal interstitial nucleus (BIN) of the cerebellum provides diffuse ascending inhibitory input to the floccular granule cell layer
    Authors: Dick Jaarsma, Francois G. C. Blot, Bin Wu, Subramanian Venkatesan, Jan Voogd, Dies Meijer et al.
    Journal of Comparative Neurology
  47. Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis
    Authors: T Rahim, P Becquart, ME Baeva, J Quandt
    J Neuroinflammation, 2018-09-19;15(1):270.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  48. Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels
    Authors: Adrián Cárdenas, Ana Villalba, Camino de Juan Romero, Esther Picó, Christina Kyrousi, Athanasia C. Tzika et al.
    Cell
  49. BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors
    Authors: GW Rhyasen, Y Yao, J Zhang, A Dulak, L Castriotta, K Jacques, W Zhao, F Gharahdagh, MM Hattersley, PD Lyne, E Clark, M Zinda, SE Fawell, GB Mills, H Chen
    PLoS ONE, 2018-07-23;13(7):e0200826.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  50. Growth Differentiation Factor 11 Promotes Neurovascular Recovery After Stroke in Mice
    Authors: Lu Lu, Xiaofei Bai, Yongliang Cao, Haiyu Luo, Xing Yang, Lijing Kang et al.
    Frontiers in Cellular Neuroscience
  51. Tis21-gene therapy inhibits medulloblastoma growth in a murine allograft model
    Authors: Dario Presutti, Manuela Ceccarelli, Laura Micheli, Giuliana Papoff, Simonetta Santini, Simone Samperna et al.
    PLOS ONE
  52. Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood
    Authors: Nora Hagemeyer, Klara-Maria Hanft, Maria-Anna Akriditou, Nicole Unger, Eun S. Park, E. Richard Stanley et al.
    Acta Neuropathologica
  53. Terminal Differentiation of Adult Hippocampal Progenitor Cells Is a Step Functionally Dissociable from Proliferation and Is Controlled by Tis21, Id3 and NeuroD2
    Authors: Laura Micheli, Manuela Ceccarelli, Roberta Gioia, Giorgio D’Andrea, Stefano Farioli-Vecchioli, Marco Costanzi et al.
    Frontiers in Cellular Neuroscience
  54. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury
    Nat Med, 2016-09-26;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  55. PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic–ischemic encephalopathy model
    Authors: Vuk Palibrk, Rajikala Suganthan, Katja Scheffler, Wei Wang, Magnar Bjørås, Stig Ove Bøe
    Cell Death & Disease
  56. BDNF Pretreatment of Human Embryonic-Derived Neural Stem Cells Improves Cell Survival and Functional Recovery after Transplantation in Hypoxic–Ischemic Stroke
    Authors: Sahar Rosenblum, Tenille N. Smith, Nancy Wang, Joshua Y. Chua, Erick Westbroek, Kendrick Wang et al.
    Cell Transplantation
  57. SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes
    Authors: Anna M. Knapinska, Daniela Dreymuller, Andreas Ludwig, Lyndsay Smith, Vladislav Golubkov, Anjum Sohail et al.
    Journal of Medicinal Chemistry
  58. Fibroblast-derived neuregulin 1 promotes compensatory ErbB3 receptor signaling in mutant BRAF melanoma.
    Authors: Capparelli C, Rosenbaum S, Berger A, Aplin A
    J Biol Chem, 2015-08-12;290(40):24267-77.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  59. Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC
    Authors: Kaihua Zhang, Lamont Jones, Sora Lim, Christopher A. Maher, Douglas Adkins, James Lewis et al.
    Oncotarget
  60. Deletion of ENTPD3 does not impair nucleotide hydrolysis in primary somatosensory neurons or spinal cord
    Authors: Eric McCoy, Sarah Street, Bonnie Taylor-Blake, Jason Yi, Martin Edwards, Mark Wightman et al.
    F1000Research
  61. BRCA1-IRIS inactivation sensitizes ovarian tumors to cisplatin.
    Authors: Paul B, Blanchard Z, Ridgway M, ElShamy W
    Oncogene, 2014-08-18;34(23):3036-52.
    Species: Human
    Sample Types: Cell Culture Supernates, Whole Cells
    Applications: ELISA Development (Capture), Neutralization
  62. CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity
    Authors: Graham K. Sheridan, Anita Wdowicz, Mark Pickering, Orla Watters, Paul Halley, Niamh C. O’Sullivan et al.
    Frontiers in Cellular Neuroscience
  63. RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic stroke
    Authors: Himiko Tokami, Tetsuro Ago, Hiroshi Sugimori, Junya Kuroda, Hideto Awano, Kazuo Suzuki et al.
    Brain Research
  64. FACS Array Profiling Identifies Ecto-5′ Nucleotidase as a Striatopallidal Neuron-Specific Gene Involved in Striatal-Dependent Learning
    Authors: Sabrina L. Ena, Jean-François De Backer, Serge N. Schiffmann, Alban de Kerchove d'Exaerde
    The Journal of Neuroscience
  65. Tis21 knock-out enhances the frequency of medulloblastoma in Patched1 heterozygous mice by inhibiting the Cxcl3-dependent migration of cerebellar neurons
    Authors: Stefano Farioli-Vecchioli, Irene Cinà, Manuela Ceccarelli, Laura Micheli, Luca Leonardi, Maria Teresa Ciotti et al.
    The Journal of Neuroscience
  66. CXCL16 orchestrates adenosine A3 receptor and MCP-1/CCL2 activity to protect neurons from excitotoxic cell death in the CNS
    Authors: Maria Rosito, Cristina Deflorio, Cristina Limatola, Flavia Trettel
    The Journal of Neuroscience
  67. The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene.
    Authors: Chua YL, Ito Y, Pole JC, Newman S, Chin SF, Stein RC, Ellis IO, Caldas C, O'Hare MJ, Murrell A, Edwards PA
    Oncogene, 2009-10-05;28(46):4041-52.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  68. Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus.
    Authors: Heinisch S, Kirby LG
    Neuroscience, 2009-09-10;164(3):1210-23.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  69. Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation
    Authors: L Peruzzotti, JD Bernstock, N Vicario, ASH Costa, CK Kwok, T Leonardi, LM Booty, I Bicci, B Balzarotti, G Volpe, G Mallucci, G Manferrari, M Donegà, N Iraci, A Braga, JM Hallenbeck, MP Murphy, F Edenhofer, C Frezza, S Pluchino
    Cell Stem Cell, 2018-02-22;22(3):355-368.e13.
  70. Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody
    Authors: S Cantor, W Zhang, N Delestrée, L Remédio, GZ Mentis, SJ Burden
    Elife, 2018-02-20;7(0):.
  71. Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution
    Authors: T Masuda, R Sankowski, O Staszewski, C Böttcher, L Amann, C Scheiwe, S Nessler, P Kunz, G van Loo, VA Coenen, PC Reinacher, A Michel, U Sure, R Gold, J Priller, C Stadelmann, M Prinz
    Nature, 2019-02-13;0(0):.
  72. Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling
    Authors: Liu Z, Yan M, Lei W et al.
    The Journal of clinical investigation
  73. Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons.
    Authors: Wong R, Lenart N, Hill L et al.
    Flow Cytometry Basics for the Non-Expert.
  74. Axonal injury following mild traumatic brain injury is exacerbated by repetitive insult and is linked to the delayed attenuation of NeuN expression without concomitant neuronal death in the mouse
    Authors: Ogino Y, Bernas T, Greer JE, Povlishock JT
    Brain pathology (Zurich, Switzerland)
  75. TRPA1-Mediated Src Family Kinases Activity Facilitates Cortical Spreading Depression Susceptibility and Trigeminovascular System Sensitization
    Authors: L Nie, L Jiang, JP Quinn, BD Grubb, M Wang
    International Journal of Molecular Sciences, 2021-11-12;22(22):.
  76. Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2
    Authors: Rodriguez CM, Bechek SC, Jones GL et al.
    Cell reports
  77. Efficient stimulation of retinal regeneration from M�ller glia in adult mice using combinations of proneural bHLH transcription factors
    Authors: L Todd, MJ Hooper, AK Haugan, C Finkbeiner, N Jorstad, N Radulovich, CK Wong, PC Donaldson, W Jenkins, Q Chen, F Rieke, TA Reh
    Cell Reports, 2021-10-19;37(3):109857.
  78. Removal of the Potassium Chloride Co-Transporter from the Somatodendritic Membrane of Axotomized Motoneurons Is Independent of BDNF/TrkB Signaling But Is Controlled by Neuromuscular Innervation
    Authors: Akhter ET, Griffith RW, English AW, Alvarez FJ
    eNeuro
  79. Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons
    Authors: FL Tang, L Zhao, Y Zhao, D Sun, XJ Zhu, L Mei, WC Xiong
    Cell Death Differ., 2020-01-06;0(0):.
  80. Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25-Nrf2 pathway
    Authors: T Tanaka, H Okuda, A Isonishi, Y Terada, M Kitabatake, T Shinjo, K Nishimura, S Takemura, H Furue, T Ito, K Tatsumi, A Wanaka
    Nature Immunology, 2023-01-26;0(0):.
  81. Zika virus infection at mid-gestation results in fetal cerebral cortical injury and fetal death in the olive baboon
    Authors: S Gurung, N Reuter, A Preno, J Dubaut, H Nadeau, K Hyatt, K Singleton, A Martin, WT Parks, JF Papin, DA Myers
    PLoS Pathog., 2019-01-18;15(1):e1007507.
  82. BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers
    Authors: Blanchard Z, Paul BT, Craft B, ElShamy WM.
    Breast Cancer Res.
  83. Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease
    Authors: NS Caron, AL Southwell, CC Brouwers, LD Cengio, Y Xie, HF Black, LM Anderson, S Ko, X Zhu, SJ van Devent, MM Evers, P Konstantin, MR Hayden
    Nucleic Acids Res., 2020-01-10;0(0):.
  84. Inflammatory Responses are Sex Specific in Chronic Hypoxic-Ischemic Encephalopathy.
    Authors: Al Mamun A, Yu H, Romana S, Liu F.
    Cell Transplant

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Reviews for Human Neuregulin-1/NRG1 Antibody

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