Human KOR Antibody Summary
Met1-Val380
Accession # P41145
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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KOR in HEK293 Human Cell line Transfected with KOR. KOR was detected in immersion fixed HEK293 human embryonic kidney cell line transfected with KOR (positive staining) and HEK293 human embryonic kidney cell line (wild type, negative staining) using Mouse Anti-Human KOR Monoclonal Antibody (Catalog # MAB3895) at 8 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. Staining was performed using our protocol for Fluorescent ICC Staining of Non-adherent Cells.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: KOR
KOR is a 45 kDa 7TM opioid receptor that is primarily expressed in the central nervous system and peripheral visceral pain sensory nerves. Following ligation by dynorphin peptides, KOR signaling induces analgesia, dysphoria, diuresis, and increased feeding desire. KOR also exerts neuroprotective and anti-inflammatory effects. Human KOR shares 94% amino acid sequence identity with mouse and rat KOR.
Product Datasheets
Citation for Human KOR Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides
Authors: M Meyrath, M Szpakowska, J Zeiner, L Massotte, MP Merz, T Benkel, K Simon, J Ohnmacht, JD Turner, R Krüger, V Seutin, M Ollert, E Kostenis, A Chevigné
Nat Commun, 2020-06-19;11(1):3033.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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