Human Integrin alpha 2b/CD41 Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human Integrin alpha 2b/CD41 by Western Blot. Western blot shows lysates of human platelets. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human Integrin a2b/CD41 Monoclonal Antibody (Catalog # MAB7616) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (HAF007). A specific band was detected for Integrin a2b/CD41 at approximately 130 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 5.
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Detection of Integrin alpha 2b/CD41 in Human Blood Platelets by Flow Cytometry. Human peripheral blood platelets were stained with Fluorescein-conjugated Anti-Mouse Integrin a2b/CD41 (Clone P2) and either (A) Mouse IgG1Isotype Control (MAB002) or (B) Mouse Anti-Human Integrin a2b/CD41 Mono-clonal Antibody (Catalog # MAB7616) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B). MAB7616 stains the same population as Clone P2.
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Detection of Integrin alpha 2b/CD41 in Human Blood Platelets by Flow Cytometry. Human peripheral blood platelets were stained with Mouse Anti-Human Integrin a2b/CD41 Mono-clonal Antibody (Catalog # MAB7616, filled histogram) or Mouse IgG1 Isotype Control (MAB002, open histogram) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (F0101B). View our protocol for Staining Membrane-associated Proteins.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Integrin alpha 2b/CD41
Integrin alpha 2b (ITGA2b), also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. It is cleaved into two disulfide-linked chains (114 kDa and 22 kDa) during transit through the Golgi. Integrin alpha 2b associates with Integrin beta 3 to form complexes that interact with Fibrinogen, von Willebrand factor, Fibronectin, and Vitronectin. Integrin alpha 2b is required for platelet aggregation, and defects lead to disorders of coagulation. Within the extracellular domain, human Integrin alpha 2b shares 80% and 78% amino acid sequence identity with mouse and rat Integrin alpha 2b, respectively.
Product Datasheets
Citations for Human Integrin alpha 2b/CD41 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 6
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A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites
Authors: Barry McCormick, Helen E. Craig, Julia Y. Chu, Leo M. Carlin, Marta Canel, Florian Wollweber et al.
The Journal of Immunology
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CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinoma
Authors: H Odaka, K Hiemori, A Shimoda, K Akiyoshi, H Tateno
BMC gastroenterology, 2022-03-28;22(1):153.
Species: Human
Sample Types: Serum
Applications: ELISA Detection -
Point-of-care microvolume cytometer measures platelet counts with high accuracy from capillary blood
Authors: WM Dickerson, R Yu, HU Westergren, J Paraskos, P Schatz, A Tigerstrom, A Ekman, J Sánchez, J Cheng, L Li, EY Chan
PLoS ONE, 2021-08-26;16(8):e0256423.
Species: Human
Sample Types: Plasma
Applications: Interferent Testing -
Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays
Authors: H Odaka, K Hiemori, A Shimoda, K Akiyoshi, H Tateno
FEBS Open Bio, 2021-02-03;0(0):.
Species: Human
Sample Types: Serum
Applications: ELISA Detection -
beta4GALT1 controls beta1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis
Authors: S Giannini, MM Lee-Sundlo, L Rivadeneyr, CA Di Buduo, R Burns, JT Lau, H Falet, A Balduini, KM Hoffmeiste
Nat Commun, 2020-01-17;11(1):356.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
beta4GALT1 controls beta1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis
Authors: S Giannini, MM Lee-Sundlo, L Rivadeneyr, CA Di Buduo, R Burns, JT Lau, H Falet, A Balduini, KM Hoffmeiste
Nat Commun, 2020;11(1):356.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot
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