Human IFN-alpha Antibody Summary
Applications
Binds to human interferon beta with high affinity.
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
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Preparation and Storage
Background: IFN-alpha
Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.
Product Datasheets
Citations for Human IFN-alpha Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Natural killer cells can inhibit the transmission of human cytomegalovirus in cell culture by using mechanisms from innate and adaptive immune responses.
Authors: Wu Z, Sinzger C, Reichel J, Just M, Mertens T
J Virol, 2014-12-24;89(5):2906-17.
Species: Human
Sample Types: Whole Cells
Applications: Blocking -
Neutralizing type I IFN antibodies trigger an IFN-like response in endothelial cells.
Authors: Moll HP, Freudenthaler H, Zommer A
J. Immunol., 2008-04-15;180(8):5250-6.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization
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