Human FGFR3 PE-conjugated Antibody

Catalog #: FAB766P
6 Citations Datasheet / COA / SDS

Clone 136334 was used by HLDA to establish CD designation

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FAB766P

Detection of FGF R3 in K562 Human Cell Line by Flow Cytometry.

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Citations (6)

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human FGFR3 PE-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects the IIIb and IIIc isoforms of human FGF R3 in direct ELISAs and Western blots. Does not cross-react with any isoforms of recombinant mouse (rm) FGF R3, rmFGF R2, recombinant human (rh) FGF R1, rhFGF R2, or rhFGF R4.

Source

Monoclonal Mouse IgG₁ Clone # 136334

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Pool of NS0-derived recombinant human FGF R3 alpha (IIIb) and Sf21-derived FGF R3 alpha (IIIc)

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

10 µL/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of FGF R3 in K562 Human Cell Line by Flow Cytometry. K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human FGF R3 PE-conjugated Monoclonal Antibody (Catalog # FAB766P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: FGFR3

Fibroblast Growth Factor Receptor 3 (FGF R3) is a type I transmembrane tyrosine kinase receptor that binds FGF ligands along with heparin or heparin sulfate proteoglycans as co‑factors. A segment of the membrane proximal Ig-like domain can be encoded by two different exons resulting in (IIIb) or (IIIc) isoforms. The IIIb or IIIc isoforms recognize FGF -1, -2, -4, -8b, -8e, -8f, -9, and -17b. FGF R3 plays a role in skeletal, brain, lung, intestine, kidney, and skin development.

Long Name

Fibroblast Growth Factor Receptor 3

Entrez Gene IDs

2261 (Human); 14184 (Mouse)

Alternate Names

CD333; CEK; EC 2.7.10; FGF R3; FGFR3; fibroblast growth factor receptor 3; HSFGFR3EX; JTK4; JTK4thanatophoric dwarfism

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human FGFR3 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes
Authors: Skerget, S;Penaherrera, D;Chari, A;Jagannath, S;Siegel, DS;Vij, R;Orloff, G;Jakubowiak, A;Niesvizky, R;Liles, D;Berdeja, J;Levy, M;Wolf, J;Usmani, SZ;MMRF CoMMpass Network, ;Christofferson, AW;Nasser, S;Aldrich, JL;Legendre, C;Benard, B;Miller, C;Turner, B;Kurdoglu, A;Washington, M;Yellapantula, V;Adkins, JR;Cuyugan, L;Boateng, M;Helland, A;Kyman, S;McDonald, J;Reiman, R;Stephenson, K;Tassone, E;Blanski, A;Livermore, B;Kirchhoff, M;Rohrer, DC;D'Agostino, M;Gamella, M;Collison, K;Stumph, J;Kidd, P;Donnelly, A;Zaugg, B;Toone, M;McBride, K;DeRome, M;Rogers, J;Craig, D;Liang, WS;Gutierrez, NC;Jewell, SD;Carpten, J;Anderson, KC;Cho, HJ;Auclair, D;Lonial, S;Keats, JJ;
Nature genetics
Species: Human
Sample Types:
Applications: Flow Cytometry
Semi-Automated Cell Panning for Efficient Isolation of FGFR3-Targeting Antibody
Authors: B Min, M Yoo, H Kim, M Cho, DH Nam, Y Yoon
International Journal of Molecular Sciences, 2021-06-09;22(12):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
A comprehensive characterisation of large-scale expanded human bone marrow and umbilical cord mesenchymal stem cells
Authors: C Mennan, J Garcia, S Roberts, C Hulme, K Wright
Stem Cell Res Ther, 2019-03-18;10(1):99.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts
Authors: ER Smith, SJ Tan, SG Holt, TD Hewitson
Sci Rep, 2017-06-13;7(1):3345.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
Detection and follow-up of fibroblast growth factor receptor 3 expression on bone marrow and circulating plasma cells by flow cytometry in patients with t(4;14) multiple myeloma.
Authors: Chandesris MO, Soulier J, Labaume S, Crinquette A, Repellini L, Chemin K, Malphettes M, Fieschi C, Asli B, Uzunhan Y, Fermand JP, Bories JC, Arnulf B
Br. J. Haematol., 2007-02-01;136(4):609-14.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome
Authors: Vera B. Kaiser, Lana Talmane, Yatendra Kumar, Fiona Semple, Marie MacLennan, David R. Deciphering Developmental Disorders Study et al.
Genome Research