Human Common beta Chain Antibody Summary
Gly23-Trp443
Accession # P32927
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
![Detection of Common beta Chain antibody in Human PBL antibody by Flow Cytometry. Detection of Common beta Chain antibody in Human PBL antibody by Flow Cytometry.](https://resources.rndsystems.com/images/datasheets/antibody/Common_beta_Chain_AF906_Flow_Cytometry_10782.jpg)
Detection of Common beta Chain in Human PBL by Flow Cytometry. Human peripheral blood lymphocytes were stained with Goat Anti-Human Common beta Chain Antigen Affinity-purified Polyclonal Antibody (Catalog # AF906, filled histogram) or control antibody (Catalog # AB-108-C, open histogram), followed by Fluorescein-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0109).
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Common beta Chain
The common beta chain, also known as CD131, is a transmembrane protein that associates with the ligand-specific IL-3 R alpha, IL-5 R alpha, or GM-CSF R alpha proteins to form high affinity receptor complexes. beta c is expressed on a variety of hematopoietic cells.
Product Datasheets
Citations for Human Common beta Chain Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 2
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Three lysine residues in the common beta chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling.
Authors: Lei JT, Mazumdar T, Martinez-Moczygemba M
J. Biol. Chem., 2011-09-30;286(46):40091-103.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Separate endocytic pathways regulate IL-5 receptor internalization and signaling.
Authors: Lei JT, Martinez-Moczygemba M
J. Leukoc. Biol., 2008-05-29;84(2):499-509.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot
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