Human BST-2/Tetherin (NP_004326) VersaClone cDNA

Catalog #: RDC2088 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
RDC2088

Human BST-2/Tetherin (NP_004326) VersaClone cDNA

1 Image

View All Products for BST-2/Tetherin

Product Details

Reviews

Summary Product Datasheets Data Images Background

Human BST-2/Tetherin (NP_004326) VersaClone cDNA Summary

Specifications

Source

N/A

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Human

Product Datasheets

Product Datasheet

COA

SDS

Background: BST-2/Tetherin

BST2, also known as CD317, Tetherin, and PDCA1, is a 30-35 kDa interferon-inducible protein that associates with the plasma membrane with its transmembrane segment and GPI anchor. BST2 is expressed on bone marrow stromal cells and is upregulated in breast cancer and astrocytoma. It binds to ILT7 on plasmacytoid dendritic cells and inhibits proinflammatory TLR7 and TLR9 signaling. BST2 inhibits the release of Kaposi sarcoma virus, HIV-1, and Lassa virus from infected cells, but this function is counteracted by viral proteins which directly bind and trigger the degradation of BST2.

Long Name

Bone Marrow Stromal Cell Antigen 2

Entrez Gene IDs

684 (Human); 69550 (Mouse)

Alternate Names

bone marrow stromal antigen 2; bone marrow stromal cell antigen 2; BST2; BST-2; CD317 antigen; CD317; HM1.24 Antigen; NPC-A-7; PDCA-1; Tetherin