Human Arylsulfatase A/ARSA Antibody Summary
Arg19-Ala507
Accession # AAH14210
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Arylsulfatase A/ARSA in Human Liver. Arylsulfatase A/ARSA was detected in immersion fixed paraffin-embedded sections of human liver using 1.7 µg/mL Human Arylsulfatase A/ARSA Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2485) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Arylsulfatase A/ARSA
As a member of the sulfatase family, ARSA is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet (1). The ARSA deficiency results in metachromatic leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms (2). The deduced amino acid sequence of human ARSA consists of a signal peptide (residues 1-18) and a mature chain (residues 19-507) (3). Recombinant human ARSA corresponds to the mature chain and has sulfatase activity described above.
- Lukatela, G. et al. (1998) Biochemistry 37:3654.
- Parenti, G. et al. (1997) Curr. Opin. Genet. & Dev. 7:386.
- Stein, C. et al. (1989) J. Biol. Chem. 264:1252.
Product Datasheets
Citations for Human Arylsulfatase A/ARSA Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Leukocyte and Dried Blood Spot Arylsulfatase A Assay by Tandem Mass Spectrometry
Authors: Xinying Hong, Arun Babu Kumar, Jessica Daiker, Fan Yi, Martin Sadilek, Fabiola De Mattia et al.
Analytical Chemistry
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Sulfatide levels correlate with severity of neuropathy in metachromatic leukodystrophy
Authors: Christine í Dali, Norman W. Barton, Mohamed H. Farah, Mihai Moldovan, Jan‐Eric Månsson, Nitin Nair et al.
Annals of Clinical and Translational Neurology
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Targeted gene transfer into ependymal cells through intraventricular injection of AAV1 vector and long-term enzyme replacement via the CSF.
Authors: Yamazaki Y, Hirai Y, Miyake K, Shimada T
Sci Rep, 2014-07-01;4(0):5506.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr
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