Human AMPK gamma 3 (NP_059127) VersaClone cDNA

Catalog #: RDC2311 Datasheet / COA / SDS

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RDC2311

Human AMPK gamma 3 (NP_059127) VersaClone cDNA

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Human AMPK gamma 3 (NP_059127) VersaClone cDNA Summary

Specifications

Source

N/A

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Human

Product Datasheets

Product Datasheet

COA

SDS

Background: AMPK gamma 3

AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic a subunit and regulatory beta and gamma subunits. Each subunit exists as alternate isoforms (alpha 1, alpha 2, beta 1, beta 2, gamma 1, gamma 2, gamma 3), with all 12 combinations capable of forming complexes. The catalytic a subunit of AMPK is activated allosterically by AMP and by phosphorylation via the AMPK kinase LKB1. Active AMPK downregulates anabolic pathways such as fatty acid, triglyceride, and cholesterol synthesis, and up-regulates catabolic pathways such as glycolysis and fatty acid oxidation. AMPK's role in metabolic regulation has implicated this serine/threonine kinase as a therapeutic target in heart disease, obesity, and diabetes.

Long Name

AMP-activated Protein Kinase gamma 3

Entrez Gene IDs

53632 (Human); 241113 (Mouse); 301518 (Rat)

Alternate Names

5'-AMP-activated protein kinase subunit gamma-3; AMPK gamma 3; AMPK gamma-3 chain; AMPK gamma3; AMPK subunit gamma-3; AMPKG3; AMPKG3,5'-AMP-activated protein kinase, gamma-3 subunit; PRKAG3; protein kinase, AMP-activated, gamma 3 non-catalytic subunit