human Agrin (NP_940978.2) VersaClone cDNA

Catalog #: RDC3631 Datasheet / COA / SDS

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RDC3631

human Agrin (NP_940978.2) VersaClone cDNA

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human Agrin (NP_940978.2) VersaClone cDNA Summary

Specifications

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Product Datasheets

Product Datasheet

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SDS

Background: Agrin

Agrin is a 400-600 kDa heparan sulfate proteoglycan component of the extracellular matrix. Multiple forms of are generated by alternative splicing and proteolytic cleavage. Agrin binds to BMP-2, BMP-4, and TGF-beta, and it blocks BMP-induced signaling through BMPR-IA. Agrin binds to a complex of alpha-Dystroglycan, MuSK, and LRP4 on myotubes and induces the clustering of AChR and motoneuron-myotube adhesion at the neuromuscular junction. It binds the Abeta (1-40) peptide in Alzheimer’s disease plaques, promotes amyloid fibril formation, and regulates neuronal excitability. It also binds the gp41 coat protein of HIV-1 and functions as an epithelial cell-virus attachment receptor. During T cell activation, Agrin contributes to formation of the immunological synapse and regulates the threshold of T cell activation. Agrin is upregulated in hepocellular carcinoma, where it enhances cell proliferation and tumor progression.

Entrez Gene IDs

375790 (Human); 11603 (Mouse); 25592 (Rat)

Alternate Names

agrin proteoglycan; Agrin; AGRN