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HTMT dimaleate

Catalog #: 0646
2 Citations Datasheet / COA / SDS
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0646/10
0646/50
HTMT dimaleate | CAS No. 195867-54-0 | Histamine H1 Receptor Agonists
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Description: H1/ H2 agonist
Alternative Names: Histamine trifluoromethyl toluidide

Chemical Name: 6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptanecarboxamide dimaleate

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity

HTMT dimaleate is a H1 and H2 receptor agonist. 4x104 times more active than histamine in H2-mediated effects in natural suppressor cells. Increases intracellular Ca2+ and IP3 in lymphocytes through a binding site other than H1, H2 or H3.

Technical Data

M.Wt:
614.57
Formula:
C19H25F3N4O.2C4H4O4
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
195867-54-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. The effects of derivatives of histamine on natural suppressor cells.
    Khan et al.
    J.Immunol., 1986;137:308
  3. Congener derivatives and conjugates of histamine: synthesis and tissue receptor selectivity of the derivatives.
    Khan et al.
    J.Med.Chem., 1987;30:2115
  4. Histamine, histamine receptors and their role in immunomodulation: An updated systematic review.
    Shahid et al.
    Open Immunol.J., 2009;2:9

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Citations for HTMT dimaleate

The citations listed below are publications that use Tocris products. Selected citations for HTMT dimaleate include:

2 Citations: Showing 1 - 2

  1. TRPV1-lineage neurons are required for thermal sensation.
    Authors: Mishra Et al.
    Br J Ophthalmol  2011;30:582
  2. The Influence of histamine H1-receptor on liver functions in immunized rabbits.
    Authors: Tripathi Et al.
    EMBO J  2011;18:411

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