HODHBt
Chemical Name: 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one
Purity: ≥98%
Biological Activity
HODHBt is a STAT5-SUMO protein-protein interaction inhibitor. Blocks SUMOylation of phosphorylated STAT5. Reactivates latent HIV-1 reservoir in central memory T cells (TCM). Increases viral release by ~2.7-fold at a concentration of 100 μM in combination with IL-2 compared to unstimulated cells; reduces size of latent HIV-1 reservoir in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation.
Bosque et al.
Cell Rep., 2017;18:1324
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