GW 9662

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Telmisartan activates endothelial nitric oxide synthase via Ser1177 phosphorylation in vascular endothelial cells.
   Myojo, Masahiro, Nagata, Daisuke, Fujita, Daishi, Kiyosue, Arihiro, Takahashi, Masao, Satonaka, Hiroshi, Morishita, Yoshiyuk, Akimoto, Tetsu, Nagai, Ryozo, Komuro, Issei, Hirata, Yasunobu
   PLoS ONE, 2014;9(5):e96948.
2. Different immune cells mediate mechanical pain hypersensitivity in male and female mice.
   Sorge R, Mapplebeck J, Rosen S, Beggs S, Taves S, Alexander J, Martin L, Austin J, Sotocinal S, Chen D, Yang M, Shi X, Huang H, Pillon N, Bilan P, Tu Y, Klip A, Ji R, Zhang J, Salter M, Mogil J
   Nat Neurosci, 2015;18(8):1081-3.
3. Role of retinal pigment epithelial cell beta-catenin signaling in experimental proliferative vitreoretinopathy.
   Umazume K, Tsukahara R, Liu L, Fernandez de Castro J, McDonald K, Kaplan H, Tamiya S
   Am J Pathol, 2014;184(5):1419-28.
4. Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs.
   Helmy M, Helmy M, El-Mas M
   PLoS ONE, 2015;10(11):e0142303.
5. IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor γ1.
   Bendixen et al.
   Proc.Natl.Acad.Sci.U.S.A., 2001;98:2443
6. Functional consequences of cysteine modification in the ligand binding sites of peroxisone proliferator activated receptors by GW9662.
   Leesnitzer et al.
   Biochemistry, 2002;41:6640
7. GW9662, a potent antaognist of PPARγ, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARγ agonist rosiglitazone, independently of PPARγ activation.
   Seargent et al.
   Br.J.Pharmacol., 2004;143:933

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