Home / Bromodomain Inhibitors / GSK 6853

GSK 6853

Catalog #: 6198 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6198/25
6198/5
GSK 6853 | CAS No. 1910124-24-1 | Bromodomain Inhibitors
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Description: Potent and selective BRPF1 inhibitor

Chemical Name: N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxybenzamide

Purity: ≥98%

Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

GSK 6853 is a potent and selective BRPF1 inhibitor. Exhibits >1600-fold selectivity for BRPF1 over other bromodomains (pIC50 values by TR-FRET are 8.1, 5.1/4.8 and 4.7/<4.3 for BRPF1, BRPF2/3 and BRD4 BD1/2, respectively).

Negative Control also available.

Technical Data

M.Wt:
409.48
Formula:
C22H27N5O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1910124-24-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK 6853 probe summary on the SGC website.

Background References

  1. GSK6853, a chemical probe for inhibition of the BRPF1 bromodomain.
    Bamborough et al.
    ACS Med.Chem.Lett., 2016;7:552

Product Datasheets

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