Home / Lipase Inhibitors / GSK 264220A

GSK 264220A

Catalog #: 3752
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3752/10
3752/50
GSK 264220A | CAS No. 685506-42-7 | Lipase Inhibitors
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Description: Endothelial lipase and lipoprotein lipase inhibitor

Chemical Name: N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

GSK 264220A is an endothelial lipase and lipoprotein lipase inhibitor (IC50 values are 0.13 and 0.10 μM respectively).

Technical Data

M.Wt:
363.43
Formula:
C17H21N3O4S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
685506-42-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A high-throughput screen for the endothelial lipase using HDL as substrate.
    Keller et al.
    J.Biomol.Screen., 2008;13:468
  2. Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors.
    Goodman et al.
    Bioorg.Med.Chem.Letts., 2009;19:27

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Citation for GSK 264220A

The citations listed below are publications that use Tocris products. Selected citations for GSK 264220A include:

1 Citation: Showing 1 - 1

  1. Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs.
    Authors: Pastor Et al.
    J Lipid Res  2014;55:966

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