GRK2i
Purity: ≥95%
Biological Activity
GRK2i is a GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling.
Koch et al.
J.Biol.Chem., 1994;269:6193 -
A βγ dimer derived from G13 transduces the angiotensin AT1 receptor signal to stimulation of Ca2+ channels in rat portal vein myocytes.
Macrez et al.
J.Biol.Chem., 1997;272:23180 -
Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons.
Dang et al.
J.Neurosci., 2009;29:3322
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Citations for GRK2i
The citations listed below are publications that use Tocris products. Selected citations for GRK2i include:
4 Citations: Showing 1 - 4
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Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders.
Authors: Lutz Et al.
Cell Rep 2021;34:108718
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Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors.
Authors: Kirill A Et al.
Neuropsychopharmacology 2019;44:642-653
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G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
Authors: Stott Et al.
Apoptosis 2015;112:6497
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Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction.
Authors: Sierra-Fonseca Et al.
BMC Neurosci 2014;15:132
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