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Gisadenafil besylate

Catalog #: 4165
1 Citation Datasheet / COA / SDS
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4165/10
4165/50
Gisadenafil besylate | CAS No. 334827-98-4 | Phosphodiesterase Inhibitors
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Description: Potent PDE5 inhibitor; orally bioavailable
Alternative Names: UK 369003

Chemical Name: 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Gisadenafil besylate is a potent PDE5 inhibitor (IC50 = 1.23 nM). Shows >100-fold selectivity for PDE5 over PDE6. Orally bioavailable.

Technical Data

M.Wt:
677.79
Formula:
C23H33N7O5S.C6H6O3S
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
334827-98-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citation for Gisadenafil besylate

The citations listed below are publications that use Tocris products. Selected citations for Gisadenafil besylate include:

1 Citation: Showing 1 - 1

  1. Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5.
    Authors: Silva Et al.
    J Neuroinflammation  2012;9:253

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