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Ghrelin (rat)

Catalog #: 1465
22 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1465/1
Ghrelin (rat)
1 Image
Description: Endogenous ghrelin receptor agonist

Purity: ≥95%

Product Details
Citations (22)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Ghrelin (rat) is an endogenous agonist peptide for the ghrelin receptor (GHS-R1a). Produced mainly by the stomach, Ghrelinstimulates release of growth hormone from the pituitary gland in vitro and in vivo, and regulates feeding, growth and energy production.

Technical Data

M.Wt:
3314.83
Formula:
C147H245N45O42
Sequence:
GSSFLSPEHQKAQQRKESKKPPAKLQPR

(Modifications: Ser-3 = Ser(n-octanoyl))

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
258338-12-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This peptide is distributed under license from Dr. Kangawa

Background References

  1. Nutritional state-dependent ghrelin activation of vasopressin neurons via retrograde trans-neuronal-glial stimulation of excitatory GABA circuits.
    Haam J, Halmos K, Di S, Tasker J
    J Neurosci, 2014;34(18):6201-13.
  2. Ghrelin: an orexigenic and somatotrophic signal from the stomach.
    Inu
    Nat.Rev.Neurosci., 2001;2:551
  3. Ghrelin is growth-hormone-releasing acylated peptide from stomach.
    Kojima et al.
    Nature, 1999;402:656
  4. In vivo and in vitro effects of ghrelin/motilin-related peptide on GH secretion in the rat.
    Tolle et al.
    Neuroendocrinology, 2001;73:54
  5. Effects of ghrelin supplementation on the acute phase of Chagas disease in rats
    F de Paula S, CMB da Costa, LM Pereira, DFS Lessa, DL Pitol, JPM Issa, JC do Prado J, AAC Abrahão
    Parasit Vectors, 2019;12(1):532.

Product Datasheets

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Citations for Ghrelin (rat)

The citations listed below are publications that use Tocris products. Selected citations for Ghrelin (rat) include:

22 Citations: Showing 1 - 10

  1. Activation of the rat hypothalamic supramammillary nucleus by food anticipation, food restriction or ghrelin administration.
    Authors: May Et al.
    J Neuroendocrinol  2018;:e12676
  2. A Dairy-Derived Ghrelinergic Hydrolysate Modulates Food Intake In Vivo.
    Authors: Howick Et al.
    Int J Mol Sci  2018;19
  3. Acylated and unacylated ghrelin inhibit atrophy in myotubes co-cultured with colon carcinoma cells.
    Authors: Zeng Et al.
    Oncotarget  2017;8:72872
  4. MRAP2 regulates ghrelin receptor signaling and hunger sensing.
    Authors: Srisai Et al.
    Nat Commun  2017;8:713
  5. Central administration of ghrelin induces conditioned avoidance in rodents.
    Authors: Schéle Et al.
    Eur Neuropsychopharmacol  2017;27:809
  6. The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice.
    Authors: Lee Et al.
    Immune Network  2016;16:242
  7. Centrally Administered Ghrelin Acutely Influences Food Choice in Rodents.
    Authors: Schéle Et al.
    PLoS One  2016;11:e0149456
  8. Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability.
    Authors: Parent Et al.
    Int J Obes (Lond)  2015;9:284
  9. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
    Authors: Bell Et al.
    Adv Pharm Bull  2015;6:7066
  10. Ghrelin Decreases Angiogenesis, HIF-1α and VEGF Protein Levels in Chronic Hypoxia in Lung Tissue of Male Rats.
    Authors: Bavil Et al.
    PLoS One  2015;5:315
  11. Ghrelin Administration Increases the Bax/Bcl-2 Gene Expression Ratio in the Heart of Chronic Hypoxic Rats.
    Authors: Aliparasti Et al.
    Front Behav Neurosci  2015;5:195
  12. Modulation of cue-induced firing of ventral tegmental area DA neurons by leptin and ghrelin.
    Authors: Plasse Et al.
    Mol Metab  2015;39:1742
  13. Effects of Ghrelin on germ cell apoptosis and proinflammatory cytokines production in Ischemia-reperfusion of the rat testis.
    Authors: Taati Et al.
    Nat Commun  2015;13:85
  14. Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract.
    Authors: Torres-Fuentes Et al.
    Adv Pharm Bull  2014;9:e103118
  15. Ablation of AgRP neurons impairs adaption to restricted feeding.
    Authors: Tan Et al.
    Br J Pharmacol  2014;3:694
  16. Ghrelin decreases firing activity of gonadotropin-releasing hormone (GnRH) neurons in an estrous cycle and endocannabinoid signaling dependent manner.
    Authors: Farkas Et al.
    PLoS One  2013;8:e78178
  17. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    J Lab Autom  2013;38:1296
  18. Promiscuous dimerization of the GH secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling.
    Authors: Schellekens Et al.
    J Biol Chem  2013;288:181
  19. Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression.
    Authors: Watterson Et al.
    Neurosignals  2012;21:28
  20. Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype.
    Authors: Burdyga Et al.
    Am J Physiol Gastrointest Liver Physiol  2010;299:G63
  21. Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a GH secretagogue receptor.
    Authors: Thompson Et al.
    Iran J Reprod Med  2004;145:234
  22. The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin.
    Authors: Tucci Et al.
    Neuropsychopharmacology  2004;143:520

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