Home / Protein Arginine Methyltransferase Inhibitors / Furamidine dihydrochloride

Furamidine dihydrochloride

Catalog #: 5202
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5202/25
5202/5
Furamidine dihydrochloride | CAS No. 55368-40-6 | Protein Arginine Methyltransferase Inhibitors
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Description: Selective PRMT1 inhibitor

Chemical Name: 4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Furamidine dihydrochloride is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits tyrosyl-DNA phosphodiesterase 1 (TDP-1) (IC50 = 1.2 μM). Inhibits cell proliferation in leukemia cell lines, suppresses neuroblastoma tumor growth, and reduces mis-splicing in in vitro and in vivo models of myotonic dystrophy type 1. Also shows dose-dependent inhibition of platelet aggregation (IC50 = 14.8 uM). Cell-permeable.

Technical Data

M.Wt:
377.27
Formula:
C18H16N4O.2HCl
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
55368-40-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
    Yan et al.
    J.Med.Chem., 2014;57:2611

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Citations for Furamidine dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Furamidine dihydrochloride include:

5 Citations: Showing 1 - 5

  1. A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer.
    Authors: Tang Et al.
    Cell Rep.  2022;38:110417
  2. PRMT1 is an important factor for medulloblastoma cell proliferation and survival.
    Authors: Jer-Yen Et al.
    Biochem Biophys Rep  2022;32:101364
  3. Inhibition of Arginine Methylation Impairs Platelet Function.
    Authors: Marsden Et al.
    ACS Pharmacol.Transl.Sci  2021;4:1567
  4. TC-E 5003, a protein methyltransferase 1 inhibitor, activates the PKA-dependent thermogenic pathway in primary murine and human subcutaneous adipocytes.
    Authors: Min-Jung Et al.
    FEBS Lett  2020;594:2923-2930
  5. Inhibiting Arginine Methylation as a Tool to Investigate Cross-Talk with Methylation and Acetylation Post-Translational Modifications in a Glioblastoma Cell Line.
    Authors: Samuel Et al.
    Proteomes  2018;6:44

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