FTY 720
Chemical Name: 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
Purity: ≥99%
Biological Activity
FTY 720 is an S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppressant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.
Brinkmann et al.
Nat. Rev. Drug Discov., 2010;9:883 -
The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors.
Coelho et al.
J.Pharmacol.Exp.Ther., 2007;323:626 -
CD69 acts downstream of IF.-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
Shiow et al.
Nature, 2006;440:540 -
ACS chemical neuroscience molecule spotlight on gil. (fingolimod; FTY720).
Hopkins et al.
ACS Chem. Neurosci., 2011;2:116
Product Datasheets
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Citations for FTY 720
The citations listed below are publications that use Tocris products. Selected citations for FTY 720 include:
5 Citations: Showing 1 - 5
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β3-adrenergic receptor on tumor-infiltrating lymphocytes sustains IFN-γ-dependent PD-L1 expression and impairs anti-tumor immunity in neuroblastoma.
Authors: Alberto Et al.
Cancer Gene Ther 2023;30:890-904
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Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion.
Authors: George Et al.
Science 2021;373
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Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area.
Authors: Zhao Et al.
Sci Adv 2019;5:eaaw7243
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Directional Migration in Esophageal Squamous Cell Carcinoma (ESCC) is Epigenetically Regulated by SET Nuclear Oncogene, a Member of the Inhibitor of Histone Acetyltransferase Complex.
Authors: Yuan Et al.
Neoplasia 2017;19:868
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S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes.
Authors: Robert H Et al.
PLoS One 2014;9:e97196
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