FSLLRY-NH2
Purity: ≥95%
Biological Activity
FSLLRY-NH2 is a selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch. FSLLRY-NH2 inhibits C. albicans induced inflammation in oral mucosal cells in vitro.Technical Data
(Modifications: Tyr-6 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain.
Bao Y, Hou W, Liu R, Gao Y, Kong X, Yang L, Shi Z, Li W, Zheng H, Jiang S, Li C, Qin Y, Hua B
Mol Pain, 2014;10(0):28. -
Human eosinophils constitutively express a unique serine protease, PRSS33
S Toyama, N Okada, A Matsuda, H Morita, H Saito, T Fujisawa, S Nakae, H Karasuyama, K Matsumoto
Allergol Int, 2017;0(0):. -
Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts.
McLarty et al.
Hypertension, 2011;58:264 -
Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in PacT.-induced neuropathic pain.
Chen et al.
Neuroscience, 2011;193:440 -
Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice.
Andoh et al.
J.Pharmacol.Exp.Ther., 2012;343:91
Product Datasheets
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Citations for FSLLRY-NH2
The citations listed below are publications that use Tocris products. Selected citations for FSLLRY-NH2 include:
9 Citations: Showing 1 - 9
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Candida albicans Sap6 initiates oral mucosal inflammation via the protease activated receptor PAR2.
Authors: Kumar Et al.
Front Immunl 2022;13:912748
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Polarization of protease-activated receptor 2 (PAR-2) signaling is altered during airway epithelial remodeling and deciliation.
Authors: Nithin D Et al.
J Biol Chem 2020;295:6721-6740
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Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects.
Authors: Xianglan Et al.
J Allergy Clin Immunol 2019;144:426-441.e3
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Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.
Authors: Noskovičová Et al.
Am J Physiol Lung Cell Mol Physiol 2018;314:L695
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Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2
Authors: Peng Et al.
Phil. Trans. R. Soc. B 2016;371:1700
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A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid P.
Authors: White Et al.
Cell Death Dis 2015;194:142
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Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
Authors: Tripathi Et al.
Invest Ophthalmol Vis Sci 2014;55:3912
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Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases.
Authors: Eum Et al.
Am J Physiol Gastrointest Liver Physiol 2014;306:G992
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PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain.
Authors: Bao Et al.
Mol Pain 2014;10:28
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F3LLRY-NH2 was used to test its effect on positive control-induced migration.
