FR 122047 hydrochloride
Chemical Name: 1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride
Purity: ≥98%
Biological Activity
FR 122047 hydrochloride is a selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.028 and 65 μM for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor.
Dohi et al.
Eur.J.Pharmacol., 1993;243:179 -
The analgesic effect profile of FR122047, a selective cyclo-oxygenase-1 inhibitor, in chemical nociceptive models.
Ochi et al.
Eur.J.Pharmacol., 2000;391:49 -
Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis.
Ochi and Goto
Br.J.Pharmacol., 2002;135:782 -
Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles.
Tanaka et al.
J.Med.Chem., 1994;37:1189
Product Datasheets
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Citations for FR 122047 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for FR 122047 hydrochloride include:
7 Citations: Showing 1 - 7
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Arachidonic acid metabolite 19(S)-HETE induces vasorelaxation and platelet inhibition by activating prostacyclin (IP) receptor.
Authors: Tunaru Et al.
PLoS One 2016;11:e0163633
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Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor
Authors: Tunaru Et al.
PLoS One 2016;11:e0163633
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Aspirin minimized the pro-metastasis effect of sora. and improved survival by up-regulating HTATIP2 in hepatocellular carcinoma.
Authors: Lu Et al.
J Biol Chem 2013;8:e65023
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Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors.
Authors: Tunaru Et al.
PLoS One 2012;109:9179
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Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland.
Authors: Passafaro Et al.
J Virol 2011;8:138
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Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.
Authors: Chia Et al.
BMC Pharmacol 2011;11:10
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Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus.
Authors: Ray Et al.
Proc Natl Acad Sci U S A 2004;78:12964
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