Fmk
Chemical Name: 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone
Purity: ≥97%
Biological Activity
Fmk is a potent irreversible RSK1/2 inhibitor (IC50 = 15 nM). Inactivates the C-terminal auto-kinase domain activity. Suppresses RSK2 kinase activity in RSK2-expressing HNSCC cell lines. Reduces HNSCC cell invasive ability. Displays no effect on EGF-stimulated phosphorylation of ERK1 or ERK2.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structural bioinformatics-based design of selective, irreversible kinase inhibitors.
Cohen et al.
Science, 2005;308:1318 -
A clickable inhibitor reveals context-dependent autoactivation of p90 RSK.
Cohen et al.
Nat.Chem.Biol., 2007;3:156 -
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
Kang et al.
J.Clin.Invest., 2010;120:1165
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