FM19G11

Biological Activity

FM19G11 is a hypoxia inducible factor (HIF) α-subunit inhibitor (IC₅₀ = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O⁶-methylguanine DNA methyltransferase (MGMT) via HIF1α pathway, under normal and hypoxic conditions in glioblastoma cell lines.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status.
   Moreno-Manzano et al.
   J.Biol.Chem., 2010;285:1333
2. FM19G11 and ependymal progenitor/stem cell combinatory treatment enhances neuronal preservation and oligodendrogenesis after severe spinal cord injury.
   Alastrue-Agudo et al.
   Int.J.Mol.Sci., 2018;19:E200
3. FM19G11 inhibits O⁶-methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions.
   You et al.
   Cancer Med, 2018;

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