FIPI
Chemical Name: N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride
Purity: ≥98%
Biological Activity
FIPI is a potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Optimization of halopemide for phospholipase D2 inhibition.
Monovich et al.
Bioorg.Med.Chem.Lett., 2007;17:2310 -
5-fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.
Su et al.
Mol.Pharmcol., 2009;75:43
Product Datasheets
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Citations for FIPI
The citations listed below are publications that use Tocris products. Selected citations for FIPI include:
7 Citations: Showing 1 - 7
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Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus.
Authors: Tove Irene Et al.
Cell Mol Life Sci 2021;78:985-1009
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Mechanical Stretch Induces mTOR Recruitment and Activation at the Phosphatidic Acid-Enriched Macropinosome in Muscle Cell.
Authors: Lin and Liu
Front Cell Dev Biol 2019;7:78
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Role of PLD-PKCζ signaling axis in p47phox phosphorylation for activation of NADPH oxidase by angiotensin II in pulmonary artery smooth muscle cells.
Authors: Sajal Et al.
Cell Biol Int 2019;43:678-694
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Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.
Authors: Pitt Et al.
Mol Biol Cell 2017;28:2623
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The prostaglandin E2-EP3 receptor axis regulates Anaplasma phagocytophilum-mediated NLRC4 inflammasome activation.
Authors: Wang Et al.
PLoS Pathog. 2016;12:e1005803
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Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation.
Authors: Bonnefond Et al.
Int J Mol Sci 2015;20:535
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Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs.
Authors: Pastor Et al.
J Lipid Res 2014;55:966
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