Finasteride

Catalog #: 3293
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
3293/50

Finasteride | CAS No. 98319-26-7 | Other Reductase Inhibitors

1 Image

Description: Type II 5α-reductase inhibitor

Alternative Names: MK 906

Chemical Name: (5α,17β)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide

Purity: ≥99%

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Product Details

Citations (2)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Finasteride is an antiandrogen that inhibits type II 5α reductase (IC₅₀ = 65 nM). Suppresses the conversion of testosterone to dihydrotestosterone. Reduces prostatic dihydrotestosterone levels and prostate size in vivo. Orally active.

Technical Data

M.Wt:

372.54

Formula:

C₂₃H₃₆N₂O₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥99%

Storage:

Store at RT

CAS No:

98319-26-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Four-amino acid segment in steroid 5α-reductase 1 confers sensitivity to finasteride, a competitive inhibitor.
Thigpen and Russell
J.Biol.Chem., 1992;267:8577
Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia.
Gao et al.
Endocrinology, 2004;145:5420
Studies on neurosteroids XXV. Influence of a 5α-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism.
Mukai et al.
Biol.Pharm.Bull., 2008;31:1646

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Citations for Finasteride

The citations listed below are publications that use Tocris products. Selected citations for Finasteride include:

2 Citations: Showing 1 - 2

Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
Authors: Ferando and Mody
Front Neural Circuits 2013;7:144
Central 5-α reduction of testost. is required for testosterone's inhibition of the hypothalamo-pituitary-adrenal axis response to restraint stress in adult male rats.
Authors: Handa Et al.
Nat Neurosci 2013;1529:74

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