Filipin III
Chemical Name: (3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,16,27-Octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one
Purity: ≥90%
Biological Activity
Key information: filipin III is a fluorescent cholesterol stain; polyene antibiotic.Used for: fluorescent cholesterol staining. Binds sterols in fungal membranes. Also inhibits formation of the pathological form of prion protein (PrP-res) from the normal membrane-bound (PrP-sen) form.
Application: confocal microscopy.
Properties and Photophysical Data: excitation and emission maxima (λ) are 405 nm and 420-480 nm, respectively.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.
Pipalia et al.
J.Lipid Res., 2006;47:284 -
Absorption and fluorescence spectra of polyene antibiotics in the presence of cholesterol.
Castanho et al.
J.Biol.Chem., 1992;267:204 -
Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release.
Marella et al.
J.Biol.Chem., 2002;277:25457
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