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FICZ

Catalog #: 5304
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5304/1
FICZ | CAS No. 172922-91-7 | Aryl Hydrocarbon Receptor Agonists
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Description: High affinity aryl hydrocarbon receptor (AhR) agonist

Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde

Purity: ≥95%

Product Details
Citations (6)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.

Technical Data

M.Wt:
284.31
Formula:
C19H12N2O
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
172922-91-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for FICZ

The citations listed below are publications that use Tocris products. Selected citations for FICZ include:

6 Citations: Showing 1 - 6

  1. Identification of environmental factors that promote intestinal inflammation.
    Authors: Ada Et al.
    Nature  2022;611:801-809
  2. Macrophages Control the Bioavailability of Vitamin D and Vitamin D-Regulated T Cell Responses.
    Authors: Carsten Et al.
    Front Immunol  2021;12:722806
  3. Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter.
    Authors: Brian T Et al.
    Front Immunol  2021;12:715059
  4. Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons.
    Authors: Igor Et al.
    Nat Immunol  2020;21:1421-1429
  5. Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells-In Vitro Studies.
    Authors: Ewa Et al.
    Int J Mol Sci  2020;21
  6. Modeling the binding of diverse ligands within the Ah receptor ligand binding domain.
    Authors: Tagliabue Et al.
    Sci Rep  2019;9:10693

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