FGIN-1-27

Discontinued Product

0658 has been discontinued.
View all Other Translocator Protein Compounds products.
FGIN-1-27 | CAS No. 142720-24-9 | Other Translocator Protein Compounds
1 Image
Description: Potent, specific ligand for mitochondrial DBI receptor

Chemical Name: N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Binds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC50 = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation.

Technical Data

M.Wt:
436.61
Formula:
C28H37FN2O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
142720-24-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).
    Romeo et al.
    J.Pharmacol.Exp.Ther., 1992;262:971
  3. Synthesis of (2-arylindol-3-yl)acetamides as probes for mitochondrial steroidogenesis - a new mechanism of GABAA receptor modulation.
    Kozikowski et al.
    Angew.Chem.Int.Ed., 1992;31:1060

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for FGIN-1-27

The citations listed below are publications that use Tocris products. Selected citations for FGIN-1-27 include:

1 Citation: Showing 1 - 1

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for FGIN-1-27

There are currently no reviews for this product. Be the first to review FGIN-1-27 and earn rewards!

Have you used FGIN-1-27?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.