FG 7142
Chemical Name: N-Methyl-β-carboline-3-carboxamide
Purity: ≥99%
Biological Activity
FG 7142 is a benzodiazepine inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β-adrenoceptors in mouse cerebral cortex.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Evidence for an excitatory action of benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents.
Donner et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1989;340:352 -
The anxiogenic β-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex.
Knorr et al.
Brain Res., 1989;495:355 -
A single dose of FG 7142 causes long term increases in mouse cortical β-adrenoceptors.
Stanford et al.
Eur.J.Pharmacol., 1987;134:313 -
Behavioural studies with the β-carboline FG 7142 combined with related drugs in monkeys.
Wettstei
Eur.J.Pharmacol., 1989;163:219
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Citations for FG 7142
The citations listed below are publications that use Tocris products. Selected citations for FG 7142 include:
4 Citations: Showing 1 - 4
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Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systems.
Authors: Lukkes Et al.
Brain Res 2012;1443:1
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Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network.
Authors: Johnson Et al.
Life Sci 2012;107:733
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Post-weaning social isolation attenuates c-Fos expression in GABAergic interneurons in the basolateral amygdala of adult female rats.
Authors: Lukkes Et al.
Physiol Behav 2012;107:719
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The anxiogenic drug FG7142 increases self-injurious behavior in male rhesus monkeys (Macaca mulatta).
Authors: Major Et al.
J Neurosci 2009;85:753
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