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ESI 09

Catalog #: 4773
13 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4773/10
4773/50
ESI 09 | CAS No. 263707-16-0 | EPAC Inhibitors
1 Image
Description: Epac inhibitor

Chemical Name: α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile

Purity: ≥98%

Product Details
Citations (13)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ESI 09 is an EPAC inhibitor. Inhibits EPAC-mediated insulin release from pancreatic β cells. Selective for EPAC over PKA. ESI 09 decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells in vitro.

Technical Data

M.Wt:
330.77
Formula:
C16H15ClN4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
263707-16-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport
    A Guichard, P Jain, M Moayeri, R Schwartz, S Chin, L Zhu, B Cruz-Moren, JZ Liu, B Aguilar, A Hollands, SH Leppla, V Nizet, E Bier
    PLoS Pathog., 2017;13(9):e1006603.
  2. A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.
    Almahariq et al.
    Mol.Pharmacol., 2013;83:122

Product Datasheets

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Citations for ESI 09

The citations listed below are publications that use Tocris products. Selected citations for ESI 09 include:

13 Citations: Showing 1 - 10

  1. Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia.
    Authors: Derek C Et al.
    J Neurosci  2021;41:2883-2898
  2. β2-adrenergic receptor regulates ER-mitochondria contacts.
    Authors: Ginam Et al.
    Sci Rep  2021;11:21477
  3. Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1.
    Authors: Chris Et al.
    Elife  2020;9
  4. Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
    Authors: Alyson E Et al.
    Cell Chem Biol  2020;27:657-667.e6
  5. Phospho-substrate profiling of Epac-dependent protein kinase C activity.
    Authors: Diana J Et al.
    Mol Cell Biochem  2019;456:167-178
  6. Elevated glucose concentration in culture media decreases membrane trafficking of SGLT2 in LLC-PK1 cells via a cAMP/PKA-dependent pathway.
    Authors: Siddharth Et al.
    Am J Physiol Cell Physiol  2019;316:C913-C924
  7. Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype.
    Authors: Caglar Et al.
    J Immunol  2019;203:3247-3255
  8. Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis.
    Authors: Jeremy F Et al.
    Cell  2019;179:1289-1305.e21
  9. The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability.
    Authors: Cheng-Mao Et al.
    J Biol Chem  2018;293:717-730
  10. Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling.
    Authors: Perkins Et al.
    Nat.Immunol.  2018;19:1309

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